Another one which makes me a little nervouse
Acute Coronary Effects of a Fatty Meal
The long-term consequences of hyperlipidemia are well known, but can a single high-fat meal have acute coronary consequences in young, healthy men? Using transthoracic Doppler echocardiography, researchers studied coronary blood flow in the left anterior descending arteries of 15 men (mean age, 29) before, and 5 hours after, they consumed single high-fat meals (total fat, 100 g; saturated fat, 50 g; cholesterol, 300 mg). Within 1 week of consuming high-fat meals, 5 of the men underwent echocardiography before and after they ate single low-fat meals. Coronary flow reserve was calculated as the ratio of peak diastolic flow velocity (cm/second) after adenosine injection to flow velocity before injection.
Five hours after participants ate high-fat meals, mean coronary flow reserve had decreased from 4.02 to 3.30 (i.e., by 18%). For the 5 men who consumed both meals, mean coronary flow reserve decreased by 0.79 after the high-fat meal and increased by 0.07 after the low-fat meal.
Comment: A high-fat meal can impair coronary flow reserve, mainly by impairing peak coronary flow velocity. It is unknown whether such impairment can precipitate clinical events (e.g., myocardial infarction) in young, healthy people. However, if these findings apply to people with coronary artery disease, then high-fat meals could, at least theoretically, lead to cardiac ischemia in CAD patients.
— Richard Saitz MD, MPH
Published in Journal Watch April 9, 2002