Fri, Feb-05-10, 12:33
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Senior Member
Posts: 736
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Plan: Meats & Veggies
Stats: 255/167/160
BF:??/36%/25%
Progress: 93%
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I can't put my finger on what it is, but something isn't right with it.
They're studying a population that already has an incredibly high rate of obesity and T2D, for one. I know most research focuses on the extremes, but it doesn't seem reasonable to study the effects of insulin levels on a population that is already, by and large, insulin-resistant. If you're fully-insulin resistant, of course you won't gain weight. Your cells won't respond to the call to pack away the pounds.
This study [PDF] notes that hyperinsulemia causes weight gain in the young, but weight stall/loss in the aged. This sounds logical and it would be interesting to see some form of analysis on the relationship between insulin secretion, weight and insulin resistance.
Quote:
Indeed, there is prospective evidence from studies on adult Pima Indians [2,3] and Hispanic and Caucasian subjects [4–8] that insulin resistance and hyperinsulinemia are associated with lower rates of weight gain in non-diabetic individuals. On the contrary, higher levels of insulin predicted a gain in body weight and obesity in Pima Indian children [9] and in U.S. black and white young adults [12]. It has been suggested that hyperinsulinemia promotes weight gain in children and young adults, and that subsequent increase in insulin resistance and compensatory hyperinsulinemia then limits further weight gain in adults [9, 27].
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The concluding paragraph of the study was what I found to be most interesting.
Quote:
In conclusion, even moderate overall and abdominal obesity and weight gain during adulthood were independently associated with increased risk of developing hyperinsulinemia in non-diabetic middle-aged men. These prospective population-based data emphasize the importance of avoiding obesity and weight gain during adulthood to prevent hyperinsulinemia and, eventually, type 2 diabetes.
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So, independent of weight, excessive insulin levels are precursors to T2D. Anyone who knows someone diagnosed with T2D knows the diabetic lost significant amounts of weight (my father, for example, lost nearly 60 pounds over 2 to 3 months). Is that weight-loss a good trade off for the resulting diabetes?
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