You definitely need to consider the Prempro as a factor in inhibiting weight loss. I am using "natural" hormones rather than the synthetic and they actually help me lose weight. You need to find a doctor that will prescribe them and have them compounded for you. In light of recent information concerning HRT, I would consider it necessary for my health as well. If you would like more information on what I am referring to, please feel free to email me personally.