Tuesday October 16,

Press Release
SOURCE: A.P. John Institute for Cancer Research


The October Issue (Volume 57, Number 4, Pages 429-431) Of The Journal Medical Hypothesis Appears An Article About The Dysfunctional Mytochondria

This Article Reveals An Extraordinary ``Cutting Edge'' Perspective On Approaches To Cancer Research And On One Of The Cancer Killing Function Of A Promising Treatment Called Controlled Amino Acid Therapy

GREENWICH, CT --(INTERNET WIRE)--Oct 16, 2001-- Nobel Prize winner, Dr. Otto Warburg, discovered decades ago that cancer cells produce inordinate amounts of lactic acid. Over the years, cancer scientists have paid little attention to this biological phenomenon.

In a report published in the October 10th issue of Medical Hypothesis, (Volume 57, Number 4, pages 429-431), cancer scientist, Angelo P. John, Director of the A.P. John Institute for Cancer Research, of Greenwich, CT., presents scientific evidence to show why cancer cells produce extraordinary amounts of lactic acid, and the impact his findings have upon the future treatment of all cancers.

In the article titled, Dysfunctional Mitochondria and Oxygen Insufficiency Causes Cancer Cells to Produce Inordinate Amounts of Lactic Acid, an overwhelming amount of scientific data shows that the excess production of lactic acid is caused by injuries sustained in cancer cells to their cellular structures called the mitochondria. The mitochondria are compartments that produce most of the energy necessary to maintain all of the chemical activities of a cell. Without sufficient energy neither normal, or cancerous cells can sustain life.

Normally, cells derive approximately 70 percent of their daily energy needs from the mitochondria and approximately 20 percent from another process called glycolysis. The article also points out that if cancer cells cannot utilize their mitochondria they must rely almost totally upon glycolysis for their major supply of energy. This defect in the mitochondria, places cancer cells at a big disadvantage which cancer scientists and oncologists can now capitalize on.

These findings now open up an entirely new front that pharmaceutical companies can target for attacking cancer. Until now, most of the drugs developed to treat cancer, were designed to injure DNA or prevent its synthesis. Now scientists can diversify their research and develop drugs that can kill off cancer cells by attacking glycolysis and shutting of their daily energy supply.

Oncologists can also take advantage of these new findings and help shut down the energy supply to cancer cells through diet and nutrition. Dr.Chi Van Dang, a researcher at Johns Hopkins School of Medicine, reports (Proceedings of the National Academy of Science, Feb 17, 1998) the benefits of a low carbohydrate diet for most cancer patients.

Alow carbohydrate diet reduces the availability of glucose to cancer cells. All carbohydrate foods are broken down by digestive enzymes into glucose. Glucose is the only food that can be broken down into energy by glycolysis. Without sufficient glucose, most cancer cells can not survive. Equally important, is the fact that shutting off the glucose supply to the body does not harm normal cells because they can still derive all of their energy needs from their otherwise healthy mitochondria.

When carbohydrates or glucose is reduced in the diet, normal cells must burn body fat. This automatically increases the levels of ketones in the blood. It has long been known and reported in every text book on biochemistry, that ketones inhibit the activities of an enzyme in the cells called phosphofructosekinase. This enzyme plays a critical key role in glycolysis. Without the actions of this enzyme, glycolysis would shut down completely.

With the new added benefits from a low carbohydrate diet alone, we can expect to see a gradual and continual reduction in the mortality rate of cancer patients in this country, which presently exceeds more than 500,000 per year.

To review the actual article please visit www.apjohncancerinstitute.org/doctor.htm

A.P John Institute for Cancer Research
67 Arch Street
Greenwich, CT 06830

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