Mon, Sep-02-24, 13:33
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Plan: Muscle Centric
Stats: 238/152/160
BF:
Progress: 110%
Location: UK
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TWO Competing Theories of Why We Get Fat: A Breakthrough
From Gary Taubes, Unsettled Science:
Quote:
TWO Competing Theories of Why We Get Fat: A Breakthrough
Is it carbs or the calories that make us fat? The debate comes to top journal, Nature Metabolism
Last week, the journal Nature Metabolism published the latest chapter in the ongoing debate about why we get fat. The article, on which I was a co-author along with 15 influential obesity researchers, was titled “On the pathogenesis of obesity: causal models and missing pieces of the puzzle.”
It is the first article of its kind — revolutionary, in its way — but we hope not the last.
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Quote:
On the pathogenesis of obesity: causal models and missing pieces of the puzzle
Application of the physical laws of energy and mass conservation at thewhole-body level is not necessarily informative about causal mechanismsof weight gain and the development of obesity. The energy balance model(EBM) and the carbohydrate–insulin model (CIM) are two plausible theories,among several others, attempting to explain why obesity develops withinan overall common physiological framework of regulation of human energymetabolism. These models have been used to explain the pathogenesis ofobesity in individuals as well as the dramatic increases in the prevalence ofobesity worldwide over the past half century. Here, we summarize outcomesof a recent workshop in Copenhagen that brought together obesity expertsfrom around the world to discuss causal models of obesity pathogenesis.These discussions helped to operationally define commonly used terms;delineate the structure of each model, particularly focussing on areas ofoverlap and divergence; challenge ideas about the importance of purportedcausal factors for weight gain; and brainstorm on the key scientific questionsthat need to be answered. We hope that more experimental research innutrition and other related fields, and more testing of the models andtheir predictions will pave the way and provide more answers about thepathogenesis of obesity than those currently available.
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Read in full here. |
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