Low-carb-high-protein diet and long-term survival in a general population cohort
If anyone wants to see the full text, please feel free to email me. Many here are doing high fat low carb, rather than high protein. But what do you all make of this study? Could it be the methionine intake from the protein? We know from recent studies that higher intakes of methionine lead to increased mortality in animals. And restriction of this amino acid leads to longer life. If this is the case, then higher intakes of legumes as your main protein source might be better. And indeed, cultures who eat a lot of beans have less mortality. in fact, the more beans the better. Little protein, plant protein, animal protein... or...
Protein DOES upregulate IGF-1 btw, which can cause and accelerate the growth and proliferation of cancer. Hence, its a growth factor.
I'm a little concerned on some of the studies i'm seeing lately, as I can have upto 3 servings of whey protein a day!
Low-carbohydrate-high-protein diet and long-term survival in a general
population cohort.Trichopoulou A, Psaltopoulou T, Orfanos P, Hsieh CC, Trichopoulos D.
1Department of Hygiene and Epidemiology, School of Medicine, University of Athens, Athens, Greece.
Objective:We have evaluated the effects on mortality of habitual low carbohydrate-high-protein diets that are thought to contribute to weight control.Design:Cohort investigation.Setting:Adult Greek population.Subjects methods:Follow-up was performed from 1993 to 2003 in the context of the Greek component of the European Prospective Investigation into Cancer and nutrition. Participants were 22 944 healthy adults, whose diet was assessed through a validated questionnaire. Participants were distributed by increasing deciles according to protein intake or carbohydrate intake, as well as by an additive score generated by increasing decile intake of protein and decreasing decile intake of carbohydrates. Proportional hazards regression was used to assess the relation between high protein, high carbohydrate and the low carbohydrate-high protein score on the one hand and mortality on the other.
Results:During 113 230 persons years of follow-up, there were 455 deaths. In models with energy adjustment, higher intake of carbohydrates was associated with significant reduction of total mortality, whereas higher intake of protein was associated with nonsignificant increase of total mortality (per decile, mortality ratios 0.94 with 95% CI 0.89 -0.99, and 1.02 with 95% CI 0.98 -1.07 respectively). Even more predictive of higher mortality were high values of the additive low carbohydrate-high protein score (per 5 units, mortality ratio 1.22 with 95% CI 1.09 -to 1.36). Positive associations of this score were noted with respect to both cardiovascular and cancer mortality.
Conclusion:Prolonged consumption of diets low in carbohydrates and high in protein is associated with an increase in total mortality.European Journal of Clinical Nutrition advance online publication, 29 November 2006; doi:10.1038/sj.ejcn.1602557.
PMID: 17136037 [PubMed - as supplied by publisher]
-- an increase of protein intake by about 15
g/day and a decrease of carbohydrate intake by about 50 g/day) was
associated with a 22% increase in overall mortality--
--It is worth noting that in all
these models mortality tends to be inversely associated with intake of
unsaturated lipids and positively, although not always significantly, with
saturated lipids.--
Last edited by Whoa182 : Sat, Feb-17-07 at 15:26.
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