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  #1   ^
Old Tue, Sep-03-24, 07:10
Calianna's Avatar
Calianna Calianna is offline
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Plan: Atkins-ish (hypoglycemia)
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Default Many Patients Stop Weight Management Drugs Too Soon—Here’s Why That Concerns Doctors

I'm almost rendered speechless by this article. I'm still trying to figure out if this site (health.com) is reliable in any way, shape, or form, but if this article is any indication, I suspect it's just another completely unreliable site.


Quote:
Many Patients Stop Weight Management Drugs Too Soon—Here’s Why That Concerns Doctors


- A new study found that most people taking GLP-1 drugs for weight management cut their treatment short.

-People drop out of treatment mainly because they experience side effects such as nausea and diarrhea, experts said.

-Stopping a GLP-1 too early doesn't always give the drug time to work and, if the drug is taken long enough to achieve results, could result in additional weight gain.


GLP-1 drugs like Ozempic and Wegovy are soaring in popularity for their weight management benefits, but a recent report found that many people don’t stay on the treatment long enough to achieve results.

The study, conducted by Blue Health Intelligence, showed that more than 30% of people stopped taking prescribed GLP-1 drugs—formally known as glucagon-like peptide-1 receptor agonists—within four weeks of starting them.

While Wegovy has been approved by the Food and Drug Administration to treat obesity, Ozempic is often prescribed off-label for that purpose. The drugs are intended to be taken for a minimum of 12 weeks and are prescribed at a low dose that increases over time. People can usually take them for years.

Taking GLP-1s for only a month will have only a minimal effect—it can take up to five or six months to reach the full dose, said Scott Isaacs, MD, president-elect of the American Association of Clinical Endocrinology. “Many people do not lose weight on the initial starting doses and need to titrate up to higher doses in order to have a weight loss effect,” he told Health.

Not only that, stopping too early can also be risky for health, experts said.

Here’s what you need to know about the research, as well as what to consider before cutting your treatment short.

Who Was More Likely to Stop Taking Anti-Obesity Medication?

For the study, researchers used the pharmacy and medical claims data of almost 170,000 people with Blue Cross Blue Shield insurance coverage who received prescriptions for GLP-1s between 2014 and 2023. The average age of patients was 45.

They found that most people dropped out of treatment prior to 12 weeks.

Those between the ages of 18 and 34 were more likely to stop treatment, as were people with health inequities or those living in underserved health regions. Gender seemed not to affect who dropped out and who continued with their medication.

Why Do People Stop Taking Their GLP-1?

Factors that influenced whether a person stayed on their GLP-1 included whether the prescribing doctor was an endocrinologist, obesity specialist, or otherwise had expertise in weight management and obesity, researchers found. People who saw their healthcare providers more frequently after receiving the GLP-1 prescription were also more likely to continue their treatment.

The researchers speculated that some people may stop taking the medication due to side effects. The drugs can cause nausea, vomiting, and diarrhea, as well as other serious but less common adverse effects including pancreatitis, gallbladder disease, and kidney issues.

“Many prescriptions are initiated to the extraordinary patient demand, but many of the prescribers are not trained in the full set of wraparound care strategies required to manage a patient on a GLP-1,” Rekha B. Kumar, MD, an associate professor of medicine at Weill Cornell Medical College and Chief Medical Officer at Found, told Health.

Those strategies include knowing how to troubleshoot side effects rather than just stopping the medication, de-escalating treatment when appropriate, and providing behavioral support, she said.

In addition to side effects, other factors like drug shortages, costs, and limited availability also may contribute to high drop-out rates, Kumar noted.

“Long-term accessibility is a concern partially due to cost, which is why there are non-evidenced based tactics being proposed, such as stopping medicine followed by severe diets,” she said.

Can Stopping GLP-1 Treatment Early Be Harmful?

Issacs said the danger of temporarily taking GLP-1 medications is that people who stay on it for at least long enough to lose weight will lose that weight rapidly, which means they will likely also lose muscle. Though people tend to regain most of the weight they lose once they go off the drugs, they won’t necessarily gain that muscle back.

“Therefore, there is an alteration in body composition with a higher body fat percentage, which then translates to lower metabolism,” he said. “Weight cycling—losing weight and then regaining it—ultimately results in more difficulty losing weight as the metabolic rate is much lower.”

That’s why GLP-1s are FDA-approved for continuous use to treat obesity, Isaacs stressed.

How to Continue Your GLP-1 Treatment

Isaacs said the key to staying on GLP-1 medication is managing side effects.

“It is common to experience gastrointestinal side effects when initiating these medications,” he said. “Side effects usually subside after four weeks or less but may return for about four weeks each time the dose is increased.”

Because the medications work by slowing stomach emptying, they can make you feel full but also bloated. High-fat foods and eating too much can worsen the feeling, which is why Isaacs suggests laying off food as soon as you feel full.

“Even eating one or two additional bites can result in severe side effects, nausea, even vomiting,” Isaacs said. “But keeping the meals small can help a lot with side effects.”

“In my experience, most patients are able to tolerate the medication and will continue it long term if they follow these steps,” he continued.

Additionally, Kumar stressed the importance of working with a qualified doctor who can properly assess your overall health and offer strategies to help you stay on medication long-term.

If you do stop taking the medication, experts advise having a dietary program in place and cognitive support to override the potential cravings and increased hunger you may experience.

“Obesity is a chronic disease, and it does not make sense to treat a chronic lifelong condition with a temporary treatment,” Isaacs said.
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  #2   ^
Old Tue, Sep-03-24, 07:52
Calianna's Avatar
Calianna Calianna is offline
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Posts: 2,177
 
Plan: Atkins-ish (hypoglycemia)
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Oh the problems with this... so SOOOO many:

Yes it's expensive - the vast majority of people can't possibly afford these drugs without insurance paying for it.

Which brings up the issue of insurance policies concerning these drugs - the article claims that you may not see any results (weight loss) until you reach the highest dosages, which takes 5-6 months to reach. But if the insurance company doesn't see sufficient weight loss during that time, they'll cut you off. Which means that if you haven't been losing weight the whole time, you aren't likely to suddenly lose enough during that last month or two to remain in your insurance company's good graces to continue with the drug, so they'll deny coverage.

Nausea, vomiting, and diarrhea, as well as less common side effects such as pancreatitis, gallbladder disease, and kidney issues - claims that proper management of what you eat as well as specialists to treat these problems will somehow magically make all those side effects go away. From what I've seen, other drugs to control those side effects aren't very effective at all. (They also left out severe constipation because of how the drugs slow digestion) Insurance again enters the picture: how many insurers will pay a team of specialists long term to manage the drug side effects, without discontinuing coverage for the very drug that is causing the side effects?

Muscle loss early in the weight loss process, and you might not regain muscle when you (inevitably) regain weight after stopping the GLP-1: Ya think?


This just shows how ignorant the author is about how these drugs are prescribed:
Quote:
“It is common to experience gastrointestinal side effects when initiating these medications,” he said. “Side effects usually subside after four weeks or less but may return for about four weeks each time the dose is increased.

The drug dosage is increased every 4 weeks whether you've gotten used to the side effects or not, which means that until you've been on the highest dosage for 4 weeks, you could very well experience those side effects the entire time you're on the drug.

Quote:
If you do stop taking the medication, experts advise having a dietary program in place and cognitive support to override the potential cravings and increased hunger you may experience.


Potential cravings? No... more like INTENSE, undeniable cravings for foods that provide the essential nutrients you're short on after months and months on an inadequate diet.

Quote:
“Obesity is a chronic disease, and it does not make sense to treat a chronic lifelong condition with a temporary treatment,” Isaacs said.


So they somehow magically expect insurance to pay for 30-40 or more years of these drugs at $1,000+/month, assuming you reach your goal weight... but we've already seen that insurance will cut you off if you don't lose enough, quickly enough. They're not going to continue to pay that much every month just to keep you from regaining weight. And just like you can get used to the effects of lower dosages to the point where they no longer provide appetite control, you're also going to get used to the effects of the highest dosage, and that will not longer provide appetite control, so you'll end up gaining weight, even while on the drugs.

But let's go back to that monthly $1,000+ price tag for the drug itself: That's on top of payments to a team of specialists to control side effects, the cost of drugs needed to control the side effects, as well as any life threatening side effects, or side effects requiring surgery or otherwise requiring hospitalization.
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  #3   ^
Old Tue, Sep-03-24, 08:48
Ms Arielle's Avatar
Ms Arielle Ms Arielle is online now
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Posts: 19,895
 
Plan: atkins, carnivore 2023
Stats: 225/224/163 Female 5'8"
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Progress: 2%
Location: Massachusetts
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Given that a specific diet can also attain good weight loss with out the side effects of these two drugs.

Very low carb diets decrease appetite. But don't make you feel bloated and sick.

Very low carb diets loaded with meats preserves muscle mass.

Quote:

Because the medications work by slowing stomach emptying, they can make you feel full but also bloated. High-fat foods and eating too much can worsen the feeling, which is why Isaacs suggests laying off food as soon as you feel full.

“Even eating one or two additional bites can result in severe side effects, nausea, even vomiting,” Isaacs said. “But keeping the meals small can help a lot with side effects.”


Dr Atkins discusses eating until comfortably full. ,........


DANDR is so much less expensive than Wygovy. The cost and the sideeffects.
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  #4   ^
Old Tue, Sep-03-24, 14:20
Calianna's Avatar
Calianna Calianna is offline
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Plan: Atkins-ish (hypoglycemia)
Stats: 000/000/000 Female 63
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We know that some version of a LC diet will be satisfying and help just about everyone lose weight.

I realize that it's difficult to get off the carbs - that's addictive stuff!

But it doesn't help one bit that The Powers That Be keep telling us we neeeeeeeeeeeeeeed carbs, fats are EVIL, stay away from them and eat your carbs!

Look - here's a great dinner! It's only 350 calories, has 7 whole grams of protein (from plants), only one gram of that evil FAT (but not to worry, it's unsaturated so you can have a whole gram of it) and 78 g of carbs, that's almost 1/3 of your daily minimum quota of carbs! You can even enjoy it with another 22 g of carbs in the form of a fat-free dessert on your healthy diet!!

I mean it's no wonder people are hungry ALL the freakin' time and end up morbidly obese, when the truth is that they're only trying to do what they've been told is the healthiest way to eat, and can't figure out why they feel awful and just keep gaining weight.

And now the drug companies have figured out a way to keep them from feeling so desperately hungry while eating a "healthy" diet. This drug is so effective at stunting your appetite that you may even forget to eat.

When they take the drug (and once they're past the nausea, puking, diarrhea, etc) they suddenly realize that they simply don't care about food any more.

So the logic is that it must be THEM that's the problem, not the diet they've been told to eat. You have a chemical imbalance, here's a drug to fix that.

As Oprah said, she finally figured out that people who were naturally thin, it wasn't because they had so much willpower - they weren't even thinking about food, and that's why they didn't overeat and get fat.
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  #5   ^
Old Tue, Sep-03-24, 15:18
Ms Arielle's Avatar
Ms Arielle Ms Arielle is online now
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Posts: 19,895
 
Plan: atkins, carnivore 2023
Stats: 225/224/163 Female 5'8"
BF:
Progress: 2%
Location: Massachusetts
Default

As long time members here, we know weight is a difficult journey. 100 people can gave 100 different experiences with weight management.

This showed up on YT. Stunning $$$$$

https://youtu.be/nE4hpEKK8ew?si=zEybzLJqMthMYmq2

I learned by reading DANDR nearly cover to cover that the food was key. And for the first time in 20 years of overweight weight, I lost weight. Not a miracle but a real strategy based on prioritizing meats and very low carb veg and a few berries.

I always struggle cause the outside world pushes into my private world. And only now, can I say no and to hell with what that person thinks.

The grand children can get their vegan dishes so I'm having my steak. No one cared that my health was based on my allowed foods, but nieces could eat their veggies and some fish which is slow starvation.

When I'm in Ketosis, stringing 3 days of very low carbs, I'm sufficiently into Ketosis to keep going. Eating less, dropping to OMAD, IF, 36 h fasts.

Like I was taking a $1000 drug.

Food bill decreases. No bread, crackers, snacks, sweets. A bag of wild blueberries for $13. Beef and meats. Eggs. Some veggies.

But veggies are about as expensive as meat. Ground beef is $5/# , $ 4.50 -5.50......veggies on the whole don't have the nutrients of beef.

In my world of feeding livestock, the cost per pound of protein is the first consideration.

When I had limited funds, my kids picked out foods to put in cart. Then removed foods based on nutrition. Leaving meats and some veggies and, yogurts.


Others report a smaller food bill, too.


The doctors supporting keto is growing fast. The doctors that hold fast to conventional disease/drug solution need to change their model. But the doctors are held hostage to a system that doesn't allow healthy patients, cause that patient isn't a patient. No money to be made off a healthy person.

I'm super frustrated. No primaries taking on patients. So no basic care. No annual physical. What the he'll is our insurance paying for???

Last edited by Ms Arielle : Tue, Sep-03-24 at 15:23.
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  #6   ^
Old Wed, Sep-04-24, 05:03
JEY100's Avatar
JEY100 JEY100 is offline
Posts: 13,746
 
Plan: P:E/DDF
Stats: 225/150/169 Female 5' 9"
BF:45%/28%/25%
Progress: 134%
Location: NC
Default

How do we judge the "popularity" of diets, outside of echo-chambers, websites or FB groups that support Keto, vegan, or carnivore?

I look at the popularity of podcasts. In the Health and Fitness top 50 rankings, The Huberman Lab is now #1 and there are no longer "keto" shows. Dr Huberman suggests a balanced, mixed diet.
https://forum.lowcarber.org/showpos...3&postcount=450. Dr. Peter Attia, Dr. Gabrielle Lyon, Max Lugavere, etc...their focus is on Health and Fitness, protein if anything, not keto or low fat.

Another way judge support for a diet is to rank Google searches. Keto has fallen steadily since Jan 2019, now only 14% interest from its previous high.
Or popular books in Health, Fitness and Dieting category on Amazon. #1 is Good Energy by Dr Casey Means it is focused on Nutrition

My echo-chamber is my own neighborhood, Health and Fitness focused, both retired and young families, and few are obese. It's not keto or vegan or Wegovy (at least I haven't noticed anyone melting away). Keto stopped working for me, my own poor metabolic health and lack of results were a way to judge various diet camps.

The article on Health.com reads like a massive Product Placement.
At least readers should know how much the drugs will cost them long term.

Last edited by JEY100 : Wed, Sep-04-24 at 06:05.
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