Data on amyotrophic lateral sclerosis published by researchers at National Institute of Neurological Disorders and Stroke

NewsRx.com

09-28-07

"The etiology of several neurodegenerative disorders is thought to involve impaired mitochondrial function and oxidative stress. Coenzyme Q-10 (CoQ(10)) acts both as an antioxidant and as an electron acceptor at the level of the mitochondria," researchers in the United States report.

"In several animal models of neurodegenerative diseases including amyotrophic lateral sclerosis, Huntington's disease, and Parkinson's disease, CoQ(10) has shown beneficial effects. Based on its biochemical properties and the effects in animal models, several clinical trials evaluating CoQ(10) have been undertaken in many neurodegenerative diseases," wrote W.R. Galpern and colleagues, National Institute of Neurological Disorders and Stroke.

The researchers concluded: "CoQ(10) appears to be safe and well tolerated, and several efficacy trials are planned."

Galpern and colleagues published their study in Mitochondrion (Coenzyme Q treatment of neurodegenerative diseases of aging. Mitochondrion, 2007;7(Suppl. S):S146-S153).

For additional information, contact W.R. Galpern, National Institute of Neurological Disorders & Stroke, National Institutes of Health, 6001 Execut Blvd., Room 2225, Bethesda, MD 20892, USA.

Publisher contact information for the journal Mitochondrion is: Elsevier Science Ltd., the Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England.

Keywords: United States, Bethesda, Amyotrophic Lateral Sclerosis, Central Nervous System Disease, Clinical Trial Research, Huntington Disease, Mental Health, Motor Neuron Disease, Neurodegenerative, Neurodegenerative Disease, Neurology, National Institute of Neurological Disorders and Stroke.

This article was prepared by Pain & Central Nervous System Week editors from staff and other reports. Copyright 2007, Pain & Central Nervous System Week via NewsRx.com.

To see more of the NewsRx.com, or to subscribe, go to http://www.newsrx.com .

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