Fri, Mar-18-16, 15:20
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Senior Member
Posts: 277
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Plan: Low carb, suff. protein
Stats: 115/103/95
BF:
Progress: 60%
Location: dublin
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Quote:
Originally Posted by teaser
One thing I think could be a factor--that glucagon that didn't decrease, it's possible that the effect of glucagon on the liver's blood glucose production is partly driven by the liver's capacity to produce glucose. In a prolonged fast, the rate of gluconeogenesis is substrate-driven, as protein and carbohydrate metabolism decrease through the fast in favour of fat, availability of amino acids for glucose production decreases.
None of this says that glucagon isn't a good target for intervention, if you could find a way to do it, it would bring down glucose, that would bring down insulin.
Also, none of my babbling really detracts from Dr. Fung's statement that it's the insulin, stupid--because failure of glucagon to decrease with the carbohydrate feeding is likely due to insulin resistance by some cell or other--either the cells that themselves produce glucagon, or the cells that produce other hormones etc. that drive glucagon release.
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Teaser are you familiar with this bit of info from Prof Roger Unger.
http://diabeticmediterraneandiet.co...diabetes-model/
also
https://www.youtube.com/watch?v=VjQkqFSdDOc
He proposes a mechanism for the failure to lower glucagon appropriately and suggests it's a bigger issue than heretofore acknowledged.
Doesn't give a definite solution but may identify a mechanism, which is a first step.
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