Mon, Mar-08-10, 08:50
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Registered Member
Posts: 2,886
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Plan: Dr Dahlqvist's
Stats: 205/152/160
BF:
Progress: 118%
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I think this is an excellent well thought out paper. The full text is online free if you click the provisional PDF link in the box. Although some parts are a bit complex if you stick with it there is plenty there you will find easier. I think we are all aware of the following.
Quote:
A transition from carbohydrate to ketones for energy is a simple way to target energy metabolism in glycolysis-dependent tumor cells while enhancing the metabolic efficiency of normal cells. The shift from the metabolism of glucose to the metabolism of ketone bodies for energy is due largely to the shift in circulating levels of insulin and glucagon, key hormones that mediate energy metabolism. Insulin, which stimulates glycolysis, is reduced under dietary restriction, while glucagon, which inhibits glycolysis and mobilizes fats, is increased.
Glucose reduction not only reduces insulin, but also reduces circulating levels of IGF-1, which is necessary for driving tumor cell metabolism and growth
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