Following on from thread
http://forum.lowcarber.org/showthre...797#post7957797
I would like to focus on one Point in it that thread:
"...................
Ketosis may cause fasting hyperglycemia (high blood sugar) in some people.
..................."
The reference in Hyperlipid's post is
"OK, fasting hyperglycaemia. I have this mildly on a low carbohydrate, high saturated fat diet. My FBG is about 5.5mmol/l, ie 100mg/dl. I've discussed it here.
http://high-fat-nutrition.blogspot....resistance.html
But I do know at least one person who can achieve a FBG of 8.0mmol/l on a deeply ketogenic diet. This is 144mg/dl and not a number that I would personally wish to sustain for any period of time. This is not a standard response to marked ketosis, but unless you are checking you blood sugar levels, how would you know that it wasn't your response? A few carbs should reverse this.
"
The latest post brings you here. (I've just posted the first section. Well worth a full read)
"Physiological insulin resistance
Back in mid summer 2007 there was this thread on the Bernstein forum. Mark, posting as iwilsmar, asked about his gradual yet progressively rising fasting blood glucose (FBG) level over a 10 year period of paleolithic LC eating. Always eating less than 30g carbohydrate per day. Initially on LC his blood glucose was 83mg/dl but it has crept up, year by year, until now his FBG is up to 115mg/dl. Post prandial values are normal.
He wanted to know if he was developing diabetes.
I've been thinking about this for some time as my own FBG is usually five point something mmol/l whole blood. Converting my whole blood values to Mark's USA plasma values, this works out at about 100-120mg/dl. Normal to prediabetic in modern parlance. However my HbA1c is only 4.4%, well toward the lower end of normality and healthy. That's always assuming that I don't have some horrible problem resulting in very rapid red blood cell turnover. I don't think so..."
And ..
"However, while muscles are in "refusal mode" for glucose the least input, from food or gluconeogenesis, will rapidly spike blood glucose out of all proportion. This is fine if you stick to LC in your eating. It also means that if you take an oral glucose tolerance test you will fail and be labelled diabetic. In fact, even a single high fat meal can do this, extending insulin resistance in to the next day. Here's a reference for this.
http://www.ncbi.nlm.nih.gov/sites/e...Pubmed_RVDocSum
"
This article has links to related articles in the right hand tab that references:
Impairment of glucose tolerance in normal adults following a lowered carbohydrate intake.
http://www.ncbi.nlm.nih.gov/pubmed/10622209?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_SingleItem Supl.Pubmed_Discovery_RA&linkpos=3&log$=relatedarticles&logdbfrom=pubmed
(I can't get this link to work)
This starts to get very interesting.
The last ref'd article shows insulin resistance in 3 out of twelve and 2 out of 8 test subjects on a low-carb diet for one and three days respectively.
The questions this raises for me are what causes some and not others to experience this.
Also whether elevated blood glucose in a subject showing this effect is as harmful as elevated blood glucose in other situations.
Lastly, whether this varying response may be related to the varying experiences related on these boards to VLC (Very Low Carb) and moderate carb diets like South Beach etc.
There's many other related links I found interesting, but I'll leave it at that for now.