I've been trying it. It has an effect on adiponectin.

Life Extension says it may not work with low-carb diets, but it seems to be helping me. I started it 3 months ago when I had hit a plateau (after losing 20 lbs.). I do think it helped me move back off that plateau. I just returned to a pretty steady pound-a-week weight loss; not the 8-10 lbs/month touted.

It's easy to take - just one capsule twice a day, I didn't notice any side effects.