Yeah, I highly recommend the Glucophage XR. I take it around lunchtime and I have very little trouble with it. Even taking 2000mg. (I'm currently down to 1000mg). My doc put me on 750mg tablets which only come in the non-XR form and two weeks later I was exhausted from the diarrhea. I was never so glad than when he put me back on the XR version (but increased the dose to 2000mg.) Even with the increased dosage (at that time) I didn't have any gastrointestinal upset.