Originally Posted by Wifezilla

Calories in/calories out ignores hormone function.

"The second Golden Rule of orthodoxy is: 'A calorie is a calorie is a calorie' – no matter where it comes from. This means that if you eat X number of calories more than you use up, you will put on Y amount of weight, wherever those calories come from. However, as has been demonstrated over and over again from many studies looking at diets with equal calorie content, but different constituents, this is far from true. Dieters on fat-based diets consistently lost much more weight than dieters on carb-based diets, even though both diets had exactly the same number of calories.

Therefore, 'a calorie is a calorie is a calorie' is not so meaningful after all: a carbohydrate calorie is obviously much more fattening than a fat calorie. So obviously some calories don't count as much as others. "
http://www.second-opinions.co.uk/do...ally-count.html

"weight gain is determined by the hormonal regulation of fat tissue and not by calories-in-minus-calories-out"
http://www.nytimes.com/2007/10/28/b.../Letters-t.html

Then there is this fellow forum member who intentionally overate to try and gain wright. It didn't work
http://magicbus.myfreeforum.org/ftopic846-0-asc-0.php