I have been on Zoloft for over a year now and have lost 30 pounds doing LC (from 142 to 112lbs. ) I gained weight on Paxil, but I think I was mentally feeling so much happier that I was "happy eating". There was a direct correlation between eating more/gaining more for me. After getting a grip on the eating by replacing my habits with LC, I had no problem seeing the pounds melt away. Also, I have maintained the weight loss now for over a year.