The fact that many natural things are not safe does not necessarily mean that all unnatural things ARE safe. Certainly heavily processed foods such as trans fats and all of the (mostly high-carb) snackfoods that contain them were not around for most of mankind's history. This type of historical argument is one of the main ones for low-carbing, so I think that the amount of processing a food has undergone should be considered in a similar light if one is a believer in the low-carb WOE. Also, the less processed a food is, the easier it is to be certain of it's nutritional content. I figure that if I can't pronounce most of the ingrediants in a product, it is probably wise to avoid it.