I refer to a "neurochemical imbalance" that causes us to have emotional problems such as manic-depression or ADHD, but I'm not necessarily a big fan of drug therapies for these conditions. I don't think we have enough knowledge to understand just what is going on, and there are no doubt a whole spectrum of neurochemical combinations that makes a simple one-drug-fits-all treatment, impractical at best and detrimental in a majority of cases. In the final analysis, I don't know that we can necessarily expect to "cure" people with these afflictions, any more than we can expect to make everyone blue-eyed and six feet tall.