Just throwing my 2 cents in....glucophage was extremely difficult for my body to get used to, but at the time it was the only diabetes medication I could take. I was allergic to the others. The side effects of glucophage (diarhea, gas, bloating, nausea, and lack of appetite) helped me lose 65 pounds. Now I take glucophage regularly without problems....but I agree that no one way is right for everyone....