Compucat,

Hi! From my own experiences with my endrocronologist prescribing Glucophage (for PCOS), he explained that the drug will not help someone if they continue to eat foods that spike insulin (many carbs). Therefore, the drug can only do so much to potentiate insulin. He said that a person had to control their sugar/carb intake when taking the drug in order to get a positive result. Therefore, the person who lost weight probably modified her diet substantially (which led to weight loss). However, the potential side-effects (severe gastrointestinal distress & renal acidosis) of the drug can be dangerous as well.

Betsy