I live in an area with very high environmental levels of formadehyde, in addition to regular exposure to two-stroke engine exhaust. I take Silymarin as per the higher end of my bottle's recommendations, and NAC-N Acetyl Cysteine--as well. NAC is a source for glutathione, and glutathione is one of the rate-limiting proteins in the clearance process for toxic substances in the liver.

Silymarin makes liver cells more resistant to absorbing toxins, and I think it does something about how efficiently they use glutathione??, but it doesn't actually make more glutathione.

It's funny--my anatomy book has a whole chapter on kidney function, and only three paragraphs on liver function. You can live a long time on no kidneys (assuming dialysis), but you won't get to the end of three days on no liver.