I am so happy for you. Being on 2 grains, you should notice a difference in couple of weeks. My doctor had started me on a 1/2 grain for 2 weeks and I did not feel a difference with low of a dosage, then she upped to 1 and then to 1 1/2 and then when I seen then endo. she automatically upped to 2 grains. But you will feel a difference. Right now I am on 1 1/2 again because she added the compound T4 and I'm suppose to go have blood work done tomorrow. Keep me posted on how you're doing. There needs to be more doctors out there that actually listen to their patients. Did they not teach that in medical school? hahaha