Get yourself a copy (or drop by GNC and use theirs) of Prescription for Nutritional Healing by James and Phyllis A. Balch. Although St. John's Wort hasn't worked for me, I've had some success with 5-HTP and with Kava for anxiety. One of the nice side effects is a drop in appetite! I only use them occasionally to supplement my Zoloft (like many of the others that replied -- it's been about 7 years!) Family history often plays a big part -- I had to wake up to the fact that depression is often beyond the individual and not always something you can control through "just trying to feel good" Good luck with it -- sometimes just getting something like your diet under control can be a big step as well -- also make sure you're getting some form of exercise daily -- even if it's only a 20-30 minute walk!

PW