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Old Mon, Jul-05-04, 18:44
PeDaSp PeDaSp is offline
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Plan: Zone (changed from Atkins
Stats: 169/156.8/147 Male 170cm
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Here's an amazing quote from the actual referenced article!!:


"It has been well established that caloric restriction in the daily diet reduces tumor size in laboratory animals. Kritchevsky's studies with rats show that just a ten percent caloric restriction reduced tumor size and that a forty percent caloric restriction caused tumors to disappear completely. (l5) I contend one reason that caloric restriction results in tumor shrinkage is that it contributes to the increase of ketones in the blood. This in turn inhibits the activity of phosphofructokinase an enzyme that plays a key role in the regulation of glycolysis.


We learn in our textbooks that ketones can inhibit the functions of phosphofructokinase. (l6) On a restricted caloric intake, especially one reduced by 40%, the body must burn its own fat as a source of fuel. Fats are converted into ketones by the liver and then deposited into the blood for distribution to cells throughout the body. Normal cells can burn fats and ketones in their Krebs cycle and can survive without glycolysis. Cancer cells, however, would have difficulty surviving without a functional phosphofructokinase in glycolysis. While a forty percent reduction in calories may not be practical to reduce tumor size in humans, the same benefits may be realized with a low carbohydrate, ketogenic diet".
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