I was diagnosed as a severe hypoglycemic ( at the lab during the test my bloodsugar went to 32, it's supposed to be around 80-120. That's about as severe as you can get regarding insulin response and carb addiction. I have a blood sugar monitor to test my sugar when I feel my symptoms come on. Never had any problems with Splenda, and I don't know how much the word "extreme" means to the Hellers, but my doctor said he had never seen blood sugar so low in his practice. I personally assume that the Heller's are a little paranoid in this area, but I guess it's up to each person to figure out what works for them. So, I guess my point is, if Splenda doesn't cause insulin reactions in me, a severe hypoglycemic, i'm not sure what what type of person the Heller's are talking about. By the way, try Stevia extract as a sweetener if in doubt. I really like it, and it's all natural. Good luck to everybody!!!