I am on depo and have had no problem losing weight. When I asked my doctor about the weight gain chances on depo, I was told that it was progesterone only with no estrogen like the pill, so it shouldn't be a problem. I was warned the only problem might be increased carb cravings, but since I was on Atkins already I had mine under control.

As for the lowered labido, I had that as well. I don't know if it's the depo, the children or what. I've had problems with it before though even when not on depo. I think its a mix of hormones, depression and just blahs (ok way too much info, sorry guys)