SJW can be effective for mild to moderate depression, but is not without side-effects and some precautions. It's not known for sure how it works, but yes, it can be used successfully in place of the SSRI class of antidepressants, such as Prozac, Paxil, etc. Note, it does NOT take the place of other classes of antidepressants - lithium, MAO inhibitors, tricyclics, anti-anxiety meds.

Make sure you buy a standardized 0.3% hypericin formula. Some of the teas and powdered leaf products may contain very little of the active ingredient.

SJW does increase sensitivity to the sun. Use at least SPF 15 sunscreen, summer and winter too. In particular, there is risk to the retina of the eye from ultra-violet light sensitivity. For this reason, persons using bright light therapy for depression and S.A.D. should NOT use hypericin. There are also studies from Europe suggesting SJW can reduce the effectiveness of birth control pills. Also, can interfere with protease inhibitors used for HIV/AIDS. Most other side-effects are minor - skin rash, stomach upset, fatigue, etc. If you are currently taking antidepressants, DO NOT TAKE SJW AT THE SAME TIME. Discuss with your doctor about first discontinuing your other meds, which may need to be tapered off slowly to avoid rebound effects.

SJW may cause similar reactions as MAO inhibitors when certain foods are eaten, such as red wine, aged cheese, nitrates, etc. Best to avoid these foods, as the reaction can be severe - nausea, headache, vomiting, even anaphylaxis (requires "911")

For unbiased information about St. John's Wort, check this site http://www.sjwinfo.org/ It is strictly information, and no one is advertising or trying to sell anything.

Take care, hope this info. was helpful. ..
Doreen

[Edited by doreen T on 03-02-01 at 12:24]