i never had the roller coaster tsh, i too have been on syn. for many years, even had an operation 3 years ago for a folliculer tumor on the thyroid, it made me wacky.. my slow loss is due to premarin, (hysterectomy) i am weaning myself off it to see what happends with the weight, and i don't CHEAT. my husband lost 32 lbs. . It's tough being a women, isn't it? btw i am south of pittsburgh , what area are you from?