For me too, the waist is the problem area. Four years ago, I gained 25 lbs. in 6 months on Depo Provera. It all went around my waist. Although I have lost 3" around my waist since being on Atkins, I am very out of proportion. My pants are snug at the waist but baggy in the butt (totally a switch, I was ALWAYS a pear). I think it was the hormone manipulation of the Depo (and being over 40) that is responsible... And I really wish I had a solution to reducing the belly fat ...