View Single Post
  #443   ^
Old Wed, Oct-08-03, 18:08
korry1977's Avatar
korry1977 korry1977 is offline
Senior Member
Posts: 1,526
 
Plan: Keto
Stats: 270/265/170 Male 68 inches
BF:43%/35%/10%
Progress: 5%
Location: Houston, TX
Default

Quote from the above website:

"High-carbohydrate/low-fat diets (which is what vegetarian diets are) can also place one at a greater risk for heart disease, diabetes, and cancer due to their hyperinsulemic effects on the body"

Perhaps my explanation on Cholesterol synthesis could reveal why hyperinsulemic effects may cause this:

Cholesterol Synthesis:

anything italisiced is an enzyme

Acetyl CoA (2C which means it has 2 Carbons)
..|
..|
.\'/
Acetoacetyl CoA (4C)
..|
..| HMG-CoA Synthase
..|.(cytoplasm)
..|
.\'/
HMG-CoA (6C)
..|
..|HMG-CoA Reductase <----Gene Repressed by Cholesterol
..|........(ER).....<---- INSULIN (Positive activator of enzyme)
..|...................<---- Statin Drugs (Inhibitor of enzyme)
..|...................<---- This enzyme is the rate limiting step
.\'/
Mevalonate (6C)
..|
..|
.\'/
.\'/.............<---- Note here there has been two steps.
Farneysl PPi (15C)
..|
..|
..|
..|
.\'/
Squalene (30C)
..|
..|
.\'/
Lanosterol (30C)
..|
..|
..| NADPH
..|
..|
.\'/
Cholesterol (27C)

Cholesterol Products include:

1. Steroids (Adrenal, Ovaries, Testes)
2. Bile Acids (Liver)
3. Vitamin D
4. Cell Membranes

Obviously, some cholesterol is good for you...

However if you look at HMG-CoA Reductase and its positive activator Insulin... Some people speculate that a high amount of Insulin could cause Cholesterol deposits. That is why, some speculate, that low fat, high carb diets could cause Atherosclerosis, etc...

High insulin also drive fatty acid synthesis, triglyceride synthesis as well (citrate being a positive enhancer,) which I already have discussed.

I understand it now...
Reply With Quote