I take glucophage for Polycystic Ovarian Disease and the Insulin resistance that goes along with it (also usually indicates lipid problems). I am also hypothyroid (take synthroid). Be aware that the glucophage will give you INTENSE digestion problems to begin with (running to the bathroom with explosive you know what). Ease into it...1 pill a day for several days, then 2, and finally 3. Also, the low carb/high fat way of living also gives me stomach woes when combined with glucophage. Always take with food. Are you taking the XR or 3 X daily? Make sure your liver is checked from time to time. It is unusual, but glucophage can cause severe liver damage in some people. It should help with your weight loss and it should help your body respond to your insulin...which we lead to lower lipid levels and weight loss.

Good luck!

Elle