This is all interesting stuff.

I'm surprised to learn that muscle weakness is a side effect of metformin. You'd think, if it helps the cells absorb glucose, that it would have the opposite effect.

I've just started taking it myself. I was perscribed 250 mg at breakfast and 250 with dinner. Instead, I've been taking the 250 in the morning and the other at bedtime, to help with morning levels.

It hasn't been enough. My morning bg is down, but just a smidge and is still in the 6.5-7.0 range. Yesterday and today I've doubled the dosage.

I'm not looking forward to being yelled at by my doc - but I don't particularly want to wait for him to have to acknowledge the obvious.

Maybe I should just take the entire dosage at bedtime, stay at the 500 mg/day and not tell him ;-)