I have been on depo for about 3 1/2 years now - the best thing i ever did was get the shot. Luckily i seemed to have no side effects. I did put on about 5kg over the 3 years since i started taking it but i think that was more from my eating habits than anything else. I am happy to say i haven't had any problems losing weight while still taking it so i hope your journey goes as well Menaz