I have been on a diuretic and a beta blocker for a couple years because of high blood pressure. My doctor recommended Atkins to me and has been very supportive. After about a month on this WOE I approched him about changing my medications because of possible interference in weight loss. He doesnt want to change them at this point because they work well for me and I am losing weight but he has monitored my blood pressure and has cut the beta blocker to half the dosage of what I was taking before. All this to say - these meds dont always have an adverse effect on weightloss. Good luck to you