Cancer as a metabolic disease
http://www.nutritionandmetabolism.com/content/7/1/7
Cancer as a metabolic disease Thomas N Seyfried email and Laura M Shelton email Nutrition & Metabolism 2010, 7:7doi:10.1186/1743-7075-7-7 Published: 27 January 2010 Abstract (provisional) Emerging evidence indicates that impaired cellular energy metabolism is the defining characteristic of nearly all cancers regardless of cellular or tissue origin. In contrast to normal cells, which derive most of their usable energy from oxidative phosphorylation, most cancer cells become heavily dependent on substrate level phosphorylation to meet energy demands. Evidence is reviewed supporting a general hypothesis that genomic instability and essentially all hallmarks of cancer, including aerobic glycolysis (Warburg effect), can be linked to impaired mitochondrial function and energy metabolism. A view of cancer as primarily a metabolic disease will impact approaches to cancer management and prevention. The complete article is available as a provisional PDF. Quote:
Patrick |
Thanks for posting this link and abstract. It's fascinating. I'm very interested in the effect of intermittent fasting and carb restriction on cancer prevention and treatment, and this article (admittedly challenging for me to understand) suggests that research is pursuing answers to those questions. Many thanks!
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I think this is an excellent well thought out paper. The full text is online free if you click the provisional PDF link in the box. Although some parts are a bit complex if you stick with it there is plenty there you will find easier. I think we are all aware of the following.
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it boils down to many cancer cells need sugar to reproduce. Ill bet that study won't make a big splash in the mainstream media.
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And I bet that at least one of the 31 possible mitochondrial dysfunctions is a result of glycation, or more specifically advanced glycation end-product, just another effect of sugar.
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Cancer proliferation and therapy: the Warburg effect and quantum metabolism
those who found the original paper interesting may also enjoy this one. |
From the paper mentioned in my previous post I found this
Energy-modulating vitamins – a new combinatorial therapy prevents cancer cachexia in rat mammary carcinoma In conclusion, the above findings indicate that net ATP production was diminished in tumour-bearing animals, which ultimately leads to cancer cachexia. Treatment with EMV enhanced the activities of the Krebs cycle enzymes, and oxidative phosphorylation as a consequence enhanced ATP production. This increased amount of ATP was utilized by normal cells for their routine metabolism, reducing the cancer cachexia. In addition, the anti-carcinogenic and anti-proliferative effects of EMV suppress tumour cell proliferation. This suggests that the new combination of EMV could be of major therapeutic value in breast cancer management. They were looking at some ways improving Mitochondrial function may improve cancer prognosis. The energy-modulating vitamins used were riboflavin (45mg/kg body weight per d), niacin (100mg/kg body weight per d) and coenzyme Q10 (40mg/kg body weight per d) for 28 d. It's a rat study and scaling those amounts up to human terms results in quite high doses. But it makes me wonder if the answer to Eades/Colpo argument over metabolic advantage may be found in the many roles of mitochondria? |
Long article -- The Concept of Gamma-Glucose
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So far as I can tell, the gist is that the body turns fat into a kind of glucose that it can burn easily, while glucose in the diet can't be burned as well. However, if anyone reads this & understands it better, dish. :) |
I keep coming across studies like this one. Thanks for posting this :thup:
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Thanks for posting this.
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Very nice Thank you ! Ron
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Thanks Larry and everyone who has posted on this. I do need a little translation and really appreciate you putting your minds to the topic and your ideas out for others' benefit.
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Dr. Thomas Seyfried: A Calorie-Restricted Ketogenic Diet Could Be The Cure For Brain Cancer (Episode 302)
It's worth listening to Thomas Seyfried's interview with Jimmy Moore. |
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