"Study suggests novel treatment for heart failure"
 

I'm posting this because this study seems to cast doubt on the cholesterol-CHD link. - gotbeer

Study suggests novel treatment for heart failure

Statins may help even patients with low cholesterol

Wednesday, February 18, 2004 Posted: 8:53 AM EST (1353 GMT)

http://www.cnn.com/2004/HEALTH/cond...reut/index.html

WASHINGTON (Reuters) -- Cholesterol-lowering drugs called statins, which greatly reduce the risk of stroke and heart attack, may also help keep patients with heart failure alive even if they do not have high cholesterol, new research suggests.

Heart failure patients who took statins were 55 percent less likely to die during the year after they were prescribed the drugs than patients who did not get them, the team at the University of California Los Angeles found.

"Our results were dramatic," Dr. Gregg Fonarow, a professor of medicine who led the study, said in a statement Tuesday.

"We were surprised by the magnitude of the additional benefits of statins in patients who were already on standard medications to treat heart failure."

Heart failure is a chronic but deadly condition caused by the heart's inability to pump efficiently. It gradually enlarges as it becomes weaker and weaker.

An estimated 5 million Americans have the condition, which will kill half of them within five years. It can be caused by high blood pressure, valve disease, clogged arteries or even an infection.

Writing in the Journal of the American College of Cardiology, Fonarow and colleagues said they found that heart failure patients did better when given a statin drug no matter what the cause of their condition.

They analyzed the medical records of 551 heart-failure patients and looked to see what medications each one was given. They then looked at mortality records.

They found an overall 55 percent reduction in mortality rate for heart failure patients taking a statin a year after getting the drug. This finding held no matter whether they had high cholesterol. It was also independent of age, sex, other drugs the patients were taking and other factors such as diabetes or coronary artery disease.

The next step should be randomized clinical trials in which half of a group of patients gets a statin and half gets a placebo, said Dr. Tamara Horwich.

"If randomized clinical trials mirror our results, we may have a novel treatment for heart-failure patients," she said.

Statins may work by reducing inflammation, helping to better control the heart ventricles, or by decreasing an overactive sympathetic nervous system, Fonarow said.

WHAT ARE STATINS?

Statins are cholesterol-lowering drugs introduced in the 1980s.

They work by blocking a substance the liver needs to manufacture cholesterol. This makes the liver cells seek out cholesterol that's already circulating in the blood.

Statins have been shown to reduce your LDL cholesterol ("bad cholesterol") by up to 40 percent.

Source: Mayo Clinic

Hmmm. Now how does this tie in with the fact that many doctors think that statins cause heart failure by depleting the bodies stores of CoQ10?

Heart failure patients who took statins were 55 percent less likely to die during the year after they were prescribed the drugs than patients who did not get them, the team at the University of California Los Angeles found.


I am willing to bet that this figure represents the RELATIVE risk, which is used to inflate trivial differences in ABSOLUTE risk...